Internode length is reduced during myelination and remyelination by neurofilament medium phosphorylation in motor axons
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چکیده
منابع مشابه
Regional modulation of neurofilament organization by myelination in normal axons.
Previous studies in the hypomyelinating mouse mutant Trembler have suggested that demyelinating axons are smaller in caliber compared to normal axons, and that there are differences in the organization of axonal neurofilaments. In the normal PNS, however, the relationship between neurofilament organization and myelination has not been investigated extensively. In normal axons, only the initial ...
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The principal subunits of neurofilaments (NFs) of immature cultured sympathetic neurons have apparent Mr of 68,000 and 145,000; a 200,000 Mr subunit is also present, but at comparatively low levels. These subunits are referred to as the low (NFL), middle (NFM), and high (NFH) Mr subunits, respectively. We studied the phosphorylation of NFL and NFM in these neurons in order to characterize the N...
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Oligodendrocytes are the myelin-forming cells of the CNS. They differentiate from oligodendrocyte precursor cells (OPCs) that are produced from progenitors throughout life but more actively during the neonatal period and in response to demyelinating insults. An accurate regulation of oligodendrogenesis is required to generate oligodendrocytes during these developmental or repair processes. We h...
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Myelination in the peripheral nervous system (PNS) is induced by close contact signaling between axons and Schwann cells. Previous studies have identified membrane-bound neuregulin-1 (Nrg1) type III, expressed on the axons, as the key instructive signal that regulates Schwann cell myelination. In our recent study, we show that recombinant soluble Nrg1 elicits a similar pro-myelinating effect on...
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ژورنال
عنوان ژورنال: Experimental Neurology
سال: 2018
ISSN: 0014-4886
DOI: 10.1016/j.expneurol.2018.05.009